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Available data from the antiretroviral pregnancy registry, which includes 1st trimester exposures to indinavir more than 280 exposures , have shown no difference in the risk of overall major birth defects when compared to the 2.
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Both indinavir and telaprevir are substrates and inhibitors of the hepatic isoenzyme cyp3a4.
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the indinavir auc 0,12 h was significantly lower during the second and third trimesters when compared with post-partum table 2 .